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Friday, November 2, 2007

Researchers at Case Western University in Cleveland, Ohio have announced the creation of transgenic mice with substantially improved athletic endurance, which live and breed longer and are more aggressive than genetically unmodified siblings, and are leaner despite consuming 60% more food. The mice have been dubbed “mighty mice” or “supermice” by the popular press and have been compared to cyclist Lance Armstrong.

The changes were created by adding an extra copy of a single gene, PEPCK-C. This gene is already present in the mouse genome, but the modified gene is designed to be strongly active (transcribed) in skeletal muscle. (The natural copy of the gene, most active in the liver, continues to function normally). The gene mediates a crucial rate controlling step of gluconeogenesis and glyceroneogenesis, and its activity helps to allow energy production by the mitochondrial citric acid cycle. In the transgenics, more energy is available to muscle through the burning of fatty acids, with much less production of lactate (a chemical that leads to sore muscles when one exercises). This is not as major a change to the mouse genome as it might seem to the layperson. The PEPCK-C gene is already present in the mouse and a variety of natural mutations could likely cause similar results. The study appears today in the Journal of Biological Chemistry in a paper with lead author Parvin Hakimi from the laboratory of Richard W. Hanson.

The altered mice can run at 20 meters per minute (0.75 miles per hour or 1.2 kilometers per hour) for up to six kilometers (nearly four miles) without stopping. The average treadmill time for strenuous exercise on a 25-degree incline is 31.9 minutes, well in excess of the 19 minute average of unmodified mice. Females can breed at two and a half years of age, whereas most female mice cannot breed after the first year.

A colony of 500 mice has been bred, starting from six independent germline transformations (“founder” mice). The level of PEPCK-C in muscle is 9 units per gram of muscle as opposed to only 0.08 in normal mice. Levels of triglycerides and the number of mitochondria are also increased.

Hanson said that he did not expect that the results would be applicable to humans due to both practical and ethical considerations in addition to the fact that the genes might not function the same way in humans.

This is not the first time that the press has dubbed a genetically modified mouse a “mighty mouse”. Earlier scientists at John Hopkins University announced that they had made mice with massively increased muscle mass that were larger and stronger than their normal cousins. These alterations increased strength rather than endurance through the genetic modification of myostatin and follistatin, or by injection of a soluble form of ACVR2B to block myostatin activity in normal mice.

Saturday, February 10, 2007

The Belgrade Neonatology Institute has refused to hand over a child to her mother, after she was unable to pay her medical bills.

Macedonian Senija Roganovic, who has no health insurance of any kind and cannot come up with the money for the bill, gave birth to the baby two months ago at and owes US$8,290.91 in hospital bills.

20-year old Roganovic has been sedated for the past two months and has lost 30 pounds of weight, possibly due to anxiety over what might happen to her child. During this period the hospital only let her see the baby once and she was not allowed to breast-feed her son.

On the 7th of February, Roganovic told her story to a journalist from the daily paper Kurir. After media reports the following day, the hospital finally let the baby go yesterday.

Friday, November 17, 2006

A group of 13 teenage boys raped a 13-year old school girl in Zurich last weekend, reports the website of the German language newspaper 20 Minuten. The report says that the girl was raped repeatedly and the act was filmed on mobile phones.

Six of the suspects are Swiss nationals, two come from Serbia and Montenegro, one comes from Italy, two from the Republic of Macedonia, one from the Dominican Republic and one from Bosnia and Hercegovina. All live in Zurich.

All the suspects were arrested on Thursday. Police secured 3 mobile phones. Police say that securing the phones ensures the movies don’t get published on the Internet and cannot spark potential copycat acts.

The alleged act took place in the flat of an 18-year-old colleague of a 15-year-old friend of the victim. The victim and four of the arrested suspects attend the same school Schulhaus Buhnrain in Zurich Seebach.

According to 20 Minuten, the families of the perpetrators have now massively threatened the victim.

Verena Lang Temperli, a school official, told 20 Minuten that this case is a problem of society itself, not a problem of the school.

Thursday, January 4, 2007

Bicycle sales in Australia have recorded record sales of 1,273,781 units for 2006, exceeding car sales by 32 percent. It is the fifth year in a row that the bicycle industry has sold more than one million units, a figure yet to be realised by car manufacturers.

The Cycling Promotion Fund (CPF) spokesman Ian Christie said Australians were increasingly using bicycles as an alternative to cars. Sales rose nine percent in 2006 while the car market stalled. Mr Christie said people were looking to cut their fuel costs and improve their fitness.

Mr Christie said organisations were beginning to supply bicycles as a company vehicle. “There is an emerging trend towards people using bikes as their official company-supplied vehicle in place of the traditional company car,” he said.

“Some of Australia’s biggest corporations now have bicycle fleets, and when you add in government organisations, we now know of at least 50 organisations which operate fleets of bikes.”

“Although the company bicycle is a long way from taking over from the company car, it’s an important trend when you consider that nearly half of all cars sold are to company fleets.”

The CPF claims most commutes to work are less than 5 kilometres (3 miles) making bicycle travel a viable alternative.

Friday, January 26, 2007

Despite pleas from Big Day Out promoters to leave the national flag of Australia at home, many of the 55,000 music lovers have turned up to the Sydney event covered in it.

Co-promoter Ken West caused a stir when the flag was “banned” from this year’s Big Day Out in Sydney after organisers branded it a “gang colour” and symbol of hate. Organizers of the rock festival had planned to confiscate any flag or bandanna bearing the national symbol at the gate. The organizers defended their action claiming Sydney was “a hot bed of racism.” They had already moved the event from the traditional time, Australia Day, to avoid these “nationalistic overtones.” The Prime Minister John Howard responded by declaring that the Big Day Out should have been cancelled unless organisers reversed their decision to ban the flag.

After widespread outrage on talkback radio, and condemnation of their action by the Prime Minister and state Premiers, Australians have literally worn their hearts on their sleeves by draping the Aussie flag over their shoulders or wearing t-shirts, tattoos or bikinis with it printed on it. Event organisers allowed hundreds of fans to bring Australian flags to the event, backing down on their earlier call to leave the emblem at home.

Melissa-Rose Heap, 18-years-old, of Kogarah, said she and her friends had fashioned the Australian flag into dresses after the banning controversy.

“We made them into dresses because they said we weren’t allowed to, and that’s not right,” she said. “They shouldn’t be able to tell anyone that we can’t be proud of Australia.”

Sunday, August 1, 2010

Antelope Valley, California —The Crown Fire that has burned through 13,980 acres in the High Desert of Southern California since 2:32 pm (2232 UTC) Thursday was at 82% containment Saturday evening, according to the Los Angeles County Fire Department.

On Friday high winds caused the fire to jump the California Aqueduct and spread into the city of Palmdale. Over 2,000 residents of Leona Valley, Ana Verde, and Rancho Vista were given mandatory evacuation orders. The sky was blanketed with thick orange pyrocumulus clouds and falling ash, making the air hard to breathe.

State Governor Arnold Schwarzenegger arrived in Palmdale on Friday to survey the burned areas. “We were very fortunate to not have fires for quite some time because the air temperature was cool and we didn’t have the experiencing of dry weather and all the winds and so on, but all of a sudden the fire season kicked in as if, ‘Here we are,'” Schwarzenegger said during a press conference. “But we are ready and we have luckily distributed resources all over the state of California, so we are ready at any given time.”

The fire has so far destroyed one house and three mobile homes, damaging the roof of another and burning car garages, horse stables, and other outbuildings. Most of the more seriously threatened homes were constructed recently from fire-proof materials, with walls coated in stucco, and fire-resistant plants in the yards. Although some roads are still closed to all traffic, all existing evacuation orders were lifted late Friday night and 500 residents of Rancho Vista were told to “shelter in place” until further notice. Despite the absence of mandatory evacuation orders, over 2,000 houses, 60 commercial buildings, and 100 outbuildings are still under threat.

Throughout the night, fire crews have been battling the wildfire, assisted by cooler temperatures and lighter-than-expected winds which have enabled them to establish containment lines. “Crews went out [Friday] night and did some great work trying to complete more lines and also trying to take care of what we call ‘cat eyes’ which are embers within the perimeter of the fire, so there will be much more work being done there today,” said LACFD Captain Roland Sprewell. “But of course we’re not going to rest on our laurels today…we’re going to be vigilantly watching the winds, especially in the ridge and down in the valleys.”

At the height of the fire, 1,700 firefighters from all over California were battling the flames, although as of 12:00 pm Saturday afternoon, it has been reduced to around 1,350 personnel. 16 fire camp crew have also assisted. 250 fire engines and four bulldozers have been used. In the air, 4 Boeing 747 supertankers, 1 McDonnell Douglas DC-10 tanker, and 6 modified Sikorsky UH-60 Black Hawk helicopters known as “Firehawks” have been dropping water and red Phos-Chek slurry. The Los Angeles Sheriffs Department also increased its presence in the Antelope Valley by bringing in response teams from stations outside the AV. This afternoon, the deployment has been scaled back to three teams as the fire stabilizes and further evacuation orders become unlikely.

Three firefighters have been injured battling the fire, although all injuries are minor. One sheriff deputy was also hospitalized for smoke inhalation but has since been released.

Friday, April 3, 2009

April Fools’ Day pranks harmlessly pervaded worldwide again this year. Media outlets and internet sites have joined family, office workers, and friends to provide a wide variety of practical jokes. Ireland, France, and the United States celebrate April Fools all day, whereas a few countries celebrate jokes only until noon such as the United Kingdom, Australia, New Zealand, Canada, and South Africa.

Car and Driver claimed that GM and Chrysler were ordered out of NASCAR by the White House by the end of 2009 in order to receive any more government loans. There are press releases about this short-lived prank which received controversial feedback.

The Swiss Tourism Board has announced that volunteers were desperately needed, The Association of Mountain Cleaners “makes sure that our holiday guests can always enjoy perfect mountains. Using brooms, brushes, water and muscle power, they clean the rocks of any bird droppings.”

This year Gmail produced a new autopilot feature for April 1, 2009 which can read your email and automatically respond to every message.

BMW released its new Magnetic Tow Technology which allows your BMW to magnetically attach to the vehicle ahead of you. This enhanced technology allows the driver to remove their foot from the gas pedal and turn off the motor.

The Guardian proposed its move to Twitter, which would allow the newspaper to fit its article content into 140 character messages or “tweets”. Included in this venture was the archiving of past events reported by The Guardian, such as, “1927 OMG first successful transatlantic air flight wow, pretty cool! Boring day otherwise *sigh*”

Google’s technological break through for April Fool’s Day was CADIE, (Cognitive Autoheuristic Distributed-Intelligence Entity). By extracting internet search patterns combined with Brain Search, a part of CADIE technology, Google can now search your thoughts and memories.

Wikipedia even fooled Fox News who claimed that “every item on the home page of the user-generated site Wikipedia is fake. The featured Wikipedia article regaled the “Museum of Bad Art” in Boston.” However, each item on the main page was based on reality — even news articles such as NASA reports a shower of diamonds over the Republic of Sudan, which was based on a meteorite which passed over Sudan whose fragments did reveal diamonds upon discovery.

The Conficker Internet worm had been in the news warning of a worst case scenario when computers worldwide would be affected by the virus. Even the chief security adviser for Microsoft, Ed Gibson, didn’t want to make any predictions about what would happen. Experts just knew that it was set to go off on April 1. Several anomalous happenings were attributed to Conficker including Leroy “Mac” MacElrie who claimed to be the programmer of the Conficker worm and turned himself in to police.

Hotels.com ran an advertisement offering hotel room bookings on the moon which would be offered on European websites starting at £800 a night.

Qualcomm ingeniously revealed a new wireless networking technology called wireless convergence. Making use of the flight patterns of pigeons. They then use innovative solutions to converge the birds with wolves to protect the internal improvements.

Media outlets were not the only ones pulling pranks. Gaming websites across the internet Blizzard, Joystiq, and affiliates posted reviews and announcements of games with tongue in cheek. YouTube offered viewers a unique April Fool’s experience as videos were offered upside down. In Ireland, U2 fans received a U2opia concert on a shopping centre roof top concert rather than the real thing.